Is there Clinical Support for this combination of ingredients in ADHD-365 Maximum Strength Brain Support Tablets?

“…suggests that L-theanine and caffeine in combination are beneficial for improving performance on cognitively demanding tasks.” (Journal of Nutritional Neuroscience, 2008) [2]

“…'Headache' and ‘tired' ratings were reduced and ‘alert' ratings increased. There was also a significant positive caffeine x L-theanine interaction on delayed word recognition reaction time.” (Journal of Biological Psychology, 2008) [3]

According to the Reddit Nootropics group “The combination of L-theanine and caffeine may improve attention more than caffeine alone.” [4]

You know that relaxed feeling you get where work effortlessly flows through you?

Usually, that happens when your brain is in an alpha wave state. One of the L-theanine benefits is an increase of alpha brain waves [7], which promotes relaxed, creative, and stress-free thinking.

Theanine can even improve your memory. A 2014 study in Nutritional Neuroscience showed theanine to improve BDNF (fertilizer for your brain) by 25%, which helps improve memory and general cognitive function [8].

What type of evidence is there that Methylene Blue helps stop cognitive decline?

Methylene Blue crosses the brain-blood barrier easily to start ATP production. ATP provides energy for the brain through mitochondria respiration as an alternative electron carrier that transfers electrons without affecting mitochondrial activities. This increases cellular consumption rates and reduces anaerobic glycolysis (breaking down of sugar [ATP] to produce energy]. Rerouting mitochondrial electron transfer provides neuroprotection against chronic and acute neurological disease. Simplified, this means that Methylene Blue increases oxygen to the brain for the cell to breath (mitochondrial respiration) and transfers electrons to the cell to produce energy for function. (Yang et al, 2017) This energy production is called glycolysis where sugar is turned into fuel within the mitochondria.

Methylene Blue was shown to rescue the depletion of Dopamine in Parkinson’s Disease. (Smith et al., 2017)

Methylene Blue provides neuroprotection by destroying free radicals (superoxide) as a powerful antioxidant. (Medina and Oddo, 2011)

Methylene Blue significantly reduced cerebral ischemia reperfusion damage in a transient focal cerebral ischemia model.

Methylene Blue reduces the formation of amyloid plaques and neurofibrillary tangles and partially repairs impairments in mitochondrial function and cellular metabolism. (Oz et al., 2009) Plaque formation is the hallmark of Alzheimer Disease.

Methylene Blue is homeotic, which means its benefit is most pronounced at lower doses but produces the opposite effect at higher doses. (Rojas et al., 2011)

There are more properties associated with brain health and neuroprotection with Methylene Blue. Most important to remember is that the brain needs lots of oxygen and lots of sugar (ATP). Methylene Blue provides the chemical mechanisms for both. (Wen et al., 2011) Overall. this keeps the brain healthy.